New Anticonvulsant Agents

Anticonvulsant Agents

the only anticonvulsant labeled for the treatment of both postherpetic neuralgia and diabetic peripheral neuropathy. Valproic acid and topiramate are approved for the prevention of migraine headaches. Phenytoin is not frequently used to treat neuropathic pain due to its narrow therapeutic range, adverse effects and lack of demonstrated efficacy. In general, anecdotal reports have suggested that...

design and synthesis of isoindole derivatives as new anticonvulsant agents

Newest Targets for Anticonvulsant Agents: An Overview

Epilepsy is a neurological condition characterized by recurrent seizures influencing about 1% of the worldwide population. Despite much progress in understanding the pathogenesis of epilepsy, the molecular basis of human epilepsy still remains unclear. Common approaches for pharmacotherapy of epilepsy are still directed towards controlling the symptoms and suppression of seizures. Clinical use ...

Transient hypothyroidism induced by anticonvulsant agents.

The question whether antiepileptic drugs alter thyroid function requires a better understanding. In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism. Although both women received anticonvulsant therapy, transient hypothyroidism was observed only in the hypothyroid woman and was found after treatment with classic anticonvulsant agents (carb...

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...